Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.66 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.60 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
| ▸ | UBE2M | P61081 | 1/20 | 0.51 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.50 |
| ▸ | WNT1 | P04628 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5402061 | 0.85 | SIGMAR1 (0.68) | CHRM2CHRM1CHRM3SIGMAR1DRD4 | |
| SCHEMBL27579051 | 0.84 | SIGMAR1 (0.74) | CHRM2CHRM1CHRM3SIGMAR1DRD4 | |
| SCHEMBL18658336 | 0.80 | SIGMAR1 (0.71) | CHRM2CHRM1CHRM3SIGMAR1UBE2M | |
| SCHEMBL18658299 | 0.79 | SIGMAR1 (0.65) | SIGMAR1UBE2MDCUN1D1MCHR1 | |
| SCHEMBL13663051 | 0.78 | EPHX2 (0.69) | DRD4SLC6A5 | |
| SCHEMBL62237 | 0.78 | DRD4 (0.76) | SIGMAR1DRD4SLC6A5CXCR4HIF1A | |
| SCHEMBL7656471 | 0.78 | SIGMAR1 (0.65) | CHRM2CHRM1CHRM3SIGMAR1DRD4 | |
| SCHEMBL4390012 | 0.78 | DRD4 (0.65) | CHRM2CHRM1CHRM3SIGMAR1DRD4 | |
| SCHEMBL6865672 | 0.78 | DRD4 (0.65) | CHRM2CHRM1CHRM3SIGMAR1DRD4 | |
| SCHEMBL6712602 | 0.77 | DRD4 (0.65) | CHRM2CHRM1CHRM3SIGMAR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | MERCK PATENT GMBH (DE) | 2004-02-19 | — | — | US | disclosed |
| EP-1335912-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002042291-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | LIPC, CETP, MTTP | CHRM2 2977/4885CHRM1 2289/4885CHRM3 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.