Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | HTR1D | P28221 | 6/20 | 0.49 |
| ▸ | HTR1B | P28222 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.47 |
| ▸ | RBP4 | P02753 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6717572 | 0.90 | MAPT (0.55) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6714739 | 0.88 | HTR1A (0.62) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6718189 | 0.88 | MAPT (0.50) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6718482 | 0.87 | SMN1; SMN2 (0.55) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6720302 | 0.86 | HTR1A (0.55) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6714762 | 0.86 | MAPT (0.68) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6716503 | 0.86 | HTR1A (0.53) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6714894 | 0.85 | HTR1A (0.49) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6724729 | 0.84 | HTR1A (0.52) | HTR1AHTR1DHTR1BMAPTHTR2A | |
| SCHEMBL6716667 | 0.83 | HTR1A (0.47) | HTR1AHTR1DHTR1BMAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | claimed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | claimed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | claimed |
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |