SCHEMBL6715995

SCHEMBL6715995

CCOC(=O)C(C)Nc1cc(-c2ncnc(C(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
JAK3 P52333 4/20 0.32
JAK2 O60674 2/20 0.32
S1PR1 P21453 1/20 0.31
S1PR3 Q99500 1/20 0.31
PRKDC P78527 3/20 0.31
BDKRB1 P46663 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
PDCD1 Q15116 1/20 0.30
CD274 Q9NZQ7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6715879 0.80 PRKDC (0.33) JAK3JAK2PRKDC
SCHEMBL6716083 0.79 CYP3A4 (0.35) JAK3JAK2PRKDCMEN1KMT2A
SCHEMBL6718059 0.77 KIT (0.36) JAK3JAK2
SCHEMBL6715885 0.77 S1PR1 (0.36) JAK3JAK2S1PR1S1PR3PRKDC
SCHEMBL6715837 0.75 GAA (0.37) LMNAPRKDC
SCHEMBL8189074 0.73 MEN1 (0.34) BDKRB1MEN1KMT2A
SCHEMBL6715936 0.72 KMO (0.35) PRKDCMEN1KMT2A
SCHEMBL6715890 0.71 KIT (0.31) PRKDC
SCHEMBL6719105 0.71 KCNH2 (0.33) PRKDC
SCHEMBL6715765 0.70 KCNH2 (0.39) PRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2004-05-13 US disclosed
CN-1473155-A Pyrimidine derivatives and herbicides containing the same ס������ũҩ��ʽ���� 2004-02-04 CN disclosed
EP-1333029-A1 PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME Sumitomo Chemical Takeda Agro Company, Limited (JP) 2003-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same DDX41, CBR3, DPYD LMNA 3759/4885JAK3 4336/4885JAK2 2741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.