Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 10/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721507 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6717134 | 0.86 | L3MBTL1 (0.47) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6719674 | 0.79 | L3MBTL1 (0.46) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6721777 | 0.79 | MAPT (0.51) | RENL3MBTL1IDO1MAPTHPGD | |
| SCHEMBL6720004 | 0.77 | L3MBTL1 (0.42) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6717436 | 0.76 | MAPT (0.52) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6719951 | 0.76 | L3MBTL1 (0.47) | SMN1; SMN2RENL3MBTL1TDP1PARP14 | |
| SCHEMBL1941923 | 0.74 | IDO1 (0.53) | SMN1; SMN2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8193133 | 0.74 | IDO1 (0.53) | RENL3MBTL1IDO1 | |
| SCHEMBL5798261 | 0.74 | IDO1 (0.53) | HTR1AADRA1DADRA1AADRA1BIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-28 | — | — | US | disclosed |
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | REN, ACE, AGTR2 | SMN1; SMN2 4700/4885HTR1A 3486/4885ADRA1D 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.