SCHEMBL6719065

SCHEMBL6719065

CC(C)(C)OC(=O)NC(CCN1C(=O)c2ccccc2C1=O)C(=O)OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 3/20 0.49
AKT1 P31749 1/20 0.49
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
RAB9A P51151 1/20 0.48
CTSS P25774 4/20 0.47
SYK P43405 1/20 0.47
CTSK P43235 3/20 0.46
PPARG P37231 2/20 0.45
CTSL P07711 2/20 0.45
CTSB P07858 1/20 0.45
SCN9A Q15858 2/20 0.45
KLK7 P49862 3/20 0.44
MAPT P10636 1/20 0.44
KLK5 Q9Y337 2/20 0.44
CCKAR P32238 1/20 0.44
CCKBR P32239 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31649054 0.87 AKT1 (0.49) PPARAAKT1CTSSCTSKPPARG
SCHEMBL28538006 0.87 AKT1 (0.49) PPARAAKT1CTSSCTSKPPARG
SCHEMBL6724186 0.84 NPSR1 (0.48) AKT1CTSSCTSKCTSLCTSB
SCHEMBL22454838 0.84 PPARA (0.46) PPARAAKT1CTSSSYKCTSK
SCHEMBL29634035 0.84 PPARA (0.46) PPARAAKT1CTSSSYKCTSK
SCHEMBL5033293 0.82 MMP2 (0.46) AKT1CTSSCTSK
SCHEMBL24821096 0.82 CTSK (0.45) PPARACTSSSYKCTSKKLK7
SCHEMBL26764230 0.82 CTSK (0.45) PPARACTSSSYKCTSKKLK7
SCHEMBL22433665 0.82 PPARA (0.57) PPARACTSSSYKCTSKPPARG
SCHEMBL1094804 0.82 PPARA (0.57) PPARACTSSSYKCTSKPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112457218-B Synthesis method of 2, 4-diaminobutyric acid derivative 宁夏医科大学 2022-08-09 CN disclosed
CN-112457218-A Synthesis method of 2, 4-diaminobutyric acid derivative 宁夏医科大学 2021-03-09 CN disclosed
US-6673804-B1 PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) SANKYO COMPANY, LIMITED (JP) 2004-01-06 US disclosed
CN-1304402-A Sulfonamide derivatives SANKYO CO (JP) 2001-07-18 CN disclosed
EP-1069110-A1 SULFONAMIDE DERIVATIVES Sankyo Company Limited (JP) 2001-01-17 EP disclosed