Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21112921 | 0.92 | TSHR (0.35) | TSHRTHRBLMNA | |
| SCHEMBL7768604 | 0.90 | TSHR (0.38) | TSHRTHRBLMNAALDH1A1 | |
| SCHEMBL21112842 | 0.89 | TSHR (0.40) | TSHRTHRBLMNASLC22A1DNM1 | |
| SCHEMBL9277808 | 0.88 | TSHR (0.37) | TSHRTHRBLMNASLC22A1SLC22A2 | |
| SCHEMBL19927282 | 0.86 | TSHR (0.35) | TSHRTHRBLMNA | |
| SCHEMBL19927587 | 0.84 | TSHR (0.40) | TSHRTHRBLMNASLC22A1DNM1 | |
| SCHEMBL19926952 | 0.82 | TSHR (0.32) | TSHRTHRBLMNA | |
| SCHEMBL17088166 | 0.82 | TSHR (0.38) | TSHRTHRBLMNASLC22A1DNM1 | |
| SCHEMBL19927323 | 0.80 | OPRM1 (0.31) | TSHRTHRB | |
| SCHEMBL7768610 | 0.79 | TSHR (0.33) | TSHRTHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48547-E1 | Aminopyrimidinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS INC. (US) | 2021-05-11 | — | — | US | disclosed |
| EP-2608672-B1 | AMINOPYRIDINE- AND AMINOPYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS | SYNTRIX BIOSYSTEMS INC (US) | 2020-12-16 | — | — | EP | disclosed |
| US-RE47740-E1 | Aminopyridinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS INC. (US) | 2019-11-26 | — | — | US | disclosed |
| US-8993541-B2 | Aminopyrimidinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140256678-A1 | Aminopyrimidinecarboxamides as CXCR2 Modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| US-8779149-B2 | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators | SYNTRIX BIOSYSTEMS, INC. (US) | 2014-07-15 | — | — | US | disclosed |
| EP-2608672-A1 | AMINOPYRIDINE- AND AMINOPYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS | Syntrix Biosystems, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027289-A1 | AMINOPYRIDINE- AND AMINOPYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS | SYNTRIX BIOSYSTEMS INC. (US) | 2012-03-01 | — | — | WO | disclosed |
| US-20120046243-A1 | Aminopyridine- and Aminopyrimidinecarboxamides as CXCR2 Modulators | SYNTRIX BIOSYSTEMS INC. (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256678-A1 | Aminopyrimidinecarboxamides as CXCR2 Modulators | CXCR2, CXCR5, CXCR3 | TSHR 4199/4885THRB 4269/4885LMNA 4873/4885 |
| US-20120046243-A1 | Aminopyridine- and Aminopyrimidinecarboxamides as CXCR2 Modulators | CXCR2, CXCR5, CXCR3 | TSHR 4093/4885THRB 4199/4885LMNA 4879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.