Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 17/20 | 0.55 |
| ▸ | MMP9 | P14780 | 17/20 | 0.55 |
| ▸ | DUT | P33316 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 4/20 | 0.51 |
| ▸ | MMP14 | P50281 | 4/20 | 0.51 |
| ▸ | MMP3 | P08254 | 3/20 | 0.51 |
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.48 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719776 | 1.00 | MMP2 (0.55) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6722473 | 1.00 | MMP2 (0.55) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6722451 | 0.94 | MMP2 (0.54) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6719593 | 0.94 | MMP2 (0.54) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6722537 | 0.92 | DUT (0.55) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6727028 | 0.91 | DUT (0.49) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6724065 | 0.91 | DUT (0.51) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6719152 | 0.89 | DUT (0.49) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6723548 | 0.88 | MMP2 (0.53) | MMP2MMP9DUTMMP1MMP14 | |
| SCHEMBL6719216 | 0.86 | MMP2 (0.49) | MMP2MMP9DUTMMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |