Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 8/20 | 0.47 |
| ▸ | MMP9 | P14780 | 8/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP14 | P50281 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719776 | 0.89 | MMP2 (0.55) | DUTLMNAMMP2MMP9HTT | |
| SCHEMBL6722473 | 0.89 | MMP2 (0.55) | DUTLMNAMMP2MMP9HTT | |
| SCHEMBL6719781 | 0.89 | MMP2 (0.55) | DUTLMNAMMP2MMP9HTT | |
| SCHEMBL6724822 | 0.84 | LMNA (0.48) | DUTLMNAMMP2MMP9LTA4H | |
| SCHEMBL6722451 | 0.83 | MMP2 (0.54) | DUTMMP2MMP9ADAMTS5NR3C1 | |
| SCHEMBL6719593 | 0.83 | MMP2 (0.54) | DUTMMP2MMP9NR3C1MMP1 | |
| SCHEMBL6726794 | 0.82 | LMNA (0.48) | DUTLMNAMMP2MMP9LTA4H | |
| SCHEMBL6727028 | 0.81 | DUT (0.49) | DUTMMP2MMP9HTTNR3C1 | |
| SCHEMBL6724065 | 0.81 | DUT (0.51) | DUTLMNAMMP2MMP9HTT | |
| SCHEMBL6722537 | 0.81 | DUT (0.55) | DUTLMNAMMP2MMP9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |