Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ODC1 | P11926 | 1/20 | 0.40 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087140 | 0.87 | IAPP (0.41) | AKR1B1HIF1ASMN1; SMN2ODC1ARG1 | |
| SCHEMBL11223299 | 0.81 | ODC1 (0.41) | AKR1B1IDO1HIF1ASMN1; SMN2ODC1 | |
| SCHEMBL11327908 | 0.81 | TYR (0.43) | ODC1MEN1KMT2A | |
| SCHEMBL11327906 | 0.81 | TYR (0.43) | ODC1MEN1KMT2A | |
| SCHEMBL11089503 | 0.81 | EGFR (0.40) | HIF1AODC1MEN1RECQLKMT2A | |
| SCHEMBL2212930 | 0.79 | SMN1; SMN2 (0.60) | AKR1B1HIF1ASMN1; SMN2ODC1TAAR1 | |
| SCHEMBL11236722 | 0.78 | MAPT (0.37) | SMN1; SMN2ODC1MEN1RECQLKMT2A | |
| SCHEMBL11094621 | 0.78 | ALDH1A1 (0.40) | HIF1ASMN1; SMN2ODC1KMT2ACA12 | |
| SCHEMBL23963102 | 0.78 | ODC1 (0.38) | HIF1ASMN1; SMN2ODC1ARG1ARG2 | |
| SCHEMBL23963121 | 0.78 | ODC1 (0.38) | HIF1ASMN1; SMN2ODC1ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | GLS, DBH, APEH | AKR1B1 668/4885IDO1 1456/4885HIF1A 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.