Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18415486 | 0.90 | GRM5 (0.53) | GRM5HDAC6HDAC8KDM4CHDAC1 | |
| SCHEMBL12990668 | 0.81 | GRM5 (0.46) | GRM5HDAC6HDAC8KDM4CHDAC1 | |
| SCHEMBL9430237 | 0.79 | GRM5 (0.50) | GRM5HDAC6HDAC8KDM4CHDAC1 | |
| SCHEMBL9480522 | 0.78 | THRB (0.49) | GRM5HDAC6HDAC8KDM4CHDAC1 | |
| SCHEMBL30567678 | 0.77 | GRM5 (0.76) | GRM5HDAC6HDAC8HDAC1HPGD | |
| SCHEMBL934546 | 0.76 | TDP1 (0.49) | GRM5HDAC6HDAC8KDM4CTHRB | |
| SCHEMBL13870633 | 0.76 | GRM5 (0.48) | GRM5HDAC6HDAC8KDM4CTHRB | |
| SCHEMBL18415493 | 0.76 | HDAC6 (0.50) | GRM5HDAC6HDAC8KDM4CHDAC1 | |
| SCHEMBL6668575 | 0.75 | TGM2 (0.56) | GRM5HDAC6HDAC8KDM4CHDAC1 | |
| SCHEMBL12265800 | 0.75 | HDAC6 (0.51) | GRM5HDAC6HDAC8KDM4CTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |