Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 2/20 | 0.71 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.71 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18130077 | 0.77 | APP (0.57) | AKR1C2AKR1C1APPHNF4AHSD17B10 | |
| SCHEMBL717466 | 0.76 | APP (0.55) | AKR1C2AKR1C1APPHNF4AMAPT | |
| SCHEMBL2450399 | 0.75 | APP (0.80) | AKR1C2AKR1C1APPHNF4AHSD17B10 | |
| SCHEMBL4267409 | 0.75 | APP (0.60) | AKR1C2AKR1C1APPHNF4AHSD17B10 | |
| SCHEMBL20211704 | 0.75 | APP (0.60) | AKR1C2AKR1C1APPHNF4AHSD17B10 | |
| SCHEMBL18549484 | 0.74 | APP (0.67) | AKR1C2AKR1C1APPHNF4AHSD17B10 | |
| SCHEMBL717647 | 0.74 | APP (0.67) | AKR1C2AKR1C1APPHNF4AHSD17B10 | |
| SCHEMBL19026498 | 0.73 | APP (0.57) | AKR1C2AKR1C1APPHNF4AMAPT | |
| Diphenylacetylene SCHEMBL960609 | 0.72 | APP (1.00) | APPHSD17B10ALDH1A1CYP3A4TSHR | |
| Diphenylacetylene SCHEMBL29188592 | 0.72 | APP (1.00) | APPHSD17B10ALDH1A1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |