SCHEMBL717466

SCHEMBL717466

Clc1ccc(C#Cc2ccccc2)cc1Cl

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.55
AKR1C2 P52895 1/20 0.49
AKR1C1 Q04828 1/20 0.49
MAPT P10636 1/20 0.48
GRM5 P41594 4/20 0.44
HNF4A P41235 1/20 0.44
ASIC3 Q9UHC3 4/20 0.44
GRM4 Q14833 3/20 0.42
PYGL P06737 1/20 0.42
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
PTPRC P08575 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16598981 0.81 MAPT (0.54) APPAKR1C2AKR1C1MAPTGRM5
SCHEMBL5966257 0.78 FFAR1 (0.46) PYGLPTPRC
Diphenylacetylene SCHEMBL27628902 0.77 APP (0.92) APPMAPTGRM5HNF4AASIC3
SCHEMBL2114741 0.77 APP (0.92) APPMAPTGRM5HNF4ACA12
SCHEMBL15809275 0.77 HNF4A (0.67) APPAKR1C2AKR1C1MAPTGRM5
SCHEMBL6721147 0.76 AKR1C2 (0.71) APPAKR1C2AKR1C1MAPTGRM5
SCHEMBL717633 0.75 APP (0.67) APPMAPTGRM5CA12CA1
SCHEMBL13091317 0.75 MAPK1 (0.41) AKR1C2AKR1C1MAPTPYGLPTPRC
SCHEMBL34468095 0.75 PYGL (0.38) AKR1C2AKR1C1GRM5GRM4PYGL
SCHEMBL6364777 0.75 APP (0.75) APPMAPTGRM5HNF4AASIC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8445141-B2 Sulfonic acid group-containing polymer, method for producing the same, resin composition containing such sulfonic acid group-containing polymer, polymer electrolyte membrane, polymer electrolyte membrane/electrode assembly, and fuel cell TOYO BOSEKI KABUSHIKI KAISHA (JP) 2013-05-21 US disclosed
US-8216727-B2 Aromatic hydrocarbon based proton exchange membrane and direct methanol fuel cell using same TOYO BOSEKI KABUSHIKI KAISHA (JP) 2012-07-10 US disclosed
US-20120052411-A9 AROMATIC HYDROCARBON BASED PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME TOYO BOSEKI KABUSHIKI KAISHA (JP) 2012-03-01 US disclosed
US-20090075147-A1 Sulfonic acid group-containing polymer, method for producing the same, resin composition containing such sulfonic acid group-containing polymer, polymer electrolyte membrane, polymer electrolyte membrane/electrode assembly, and fuel cell TOYO BOSEKI KABUSHIKI KAISHA (JP) 2009-03-19 US disclosed
EP-1889863-A1 SULFONIC ACID GROUP-CONTAINING POLYMER, METHOD FOR PRODUCING SAME, RESIN COMPOSITION CONTAINING SUCH SULFONIC ACID GROUP-CONTAINING POLYMER, POLYMER ELECTROLYTE MEMBRANE, POLYMER ELECTROLYTE MEMBRANE/ELECTRODE ASSEMBLY, AND FUEL CELL Toyo Boseki Kabushiki Kasisha (JP) 2008-02-20 EP disclosed
US-20070207361-A1 AROMATIC HYDROCARBON BASED PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME TOYO BOSEKI KABUSHIKI KAISHA (JP) 2007-09-06 US disclosed
EP-1826846-A1 AROMATIC HYDROCARBON-BASE PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME Toyo Boseki Kabushiki Kasisha (JP) 2007-08-29 EP disclosed