SCHEMBL672160

SCHEMBL672160

NS(=O)(=O)c1ccc(NC(=O)NCc2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA2 P00918 14/20 1.00
CA1 P00915 11/20 1.00
CA12 O43570 10/20 1.00
CA9 Q16790 10/20 1.00
NAMPT P43490 4/20 0.75
ALDH1A1 P00352 1/20 0.72
HPGD P15428 1/20 0.72
CA7 P43166 4/20 0.67
CA5A P35218 3/20 0.67
CA14 Q9ULX7 2/20 0.67
CA4 P22748 1/20 0.67
CA5B Q9Y2D0 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20389230 0.86 NAMPT (1.00) CA2CA1CA12CA9NAMPT
SCHEMBL14726350 0.85 CA2 (0.74) CA2CA1CA12CA9NAMPT
SCHEMBL11887680 0.84 ALDH1A1 (1.00) CA2CA1CA12CA9NAMPT
SCHEMBL20388977 0.84 NAMPT (0.85) CA2CA1CA12CA9NAMPT
SCHEMBL165262 0.84 NAMPT (0.80) CA2CA1CA12CA9NAMPT
SCHEMBL31241518 0.84 NAMPT (0.80) CA2CA1CA12CA9NAMPT
SCHEMBL671546 0.82 CA2 (1.00) CA2CA1CA12CA9CA7
SCHEMBL2831462 0.82 NPC1 (0.77) CA2CA1CA12CA9NAMPT
SCHEMBL14323871 0.82 CA2 (0.67) CA2CA1CA12CA9NAMPT
SCHEMBL3461361 0.81 CA2 (0.68) CA2CA1CA12CA9NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US claimed
CN-103221388-A Novel sulfonamide compounds for inhibition of metastatic tumor growth METASIGNAL THERAPEUTICS INC 2013-07-24 CN claimed
EP-2590938-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH Metasignal Therapeutics Inc. (CA) 2013-05-15 EP claimed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO claimed
CN-115414480-A Dianhydrogalactitol in combination with radiation for treatment of non-small cell lung cancer and glioblastoma multiforme 德玛医药 2022-12-02 CN disclosed
US-20190015379-A1 USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF, TOGETHER WITH RADIATION, TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME AND SUPPRESS PROLIFERATION OF CANCER STEM CELLS DEL MAR PHARMACEUTICALS (BC) LTD. (CA) 2019-01-17 US disclosed
US-9962398-B2 Sulfonamide compounds for inhibition of metastatic tumor growth WELICHEM BIOTECH INC. (CA) 2018-05-08 US disclosed
US-9962398-B2 Sulfonamide compounds for inhibition of metastatic tumor growth WELICHEM BIOTECH INC. (CA) 2018-05-08 US disclosed
EP-3217970-A1 DIANHYDROGALACTITOL TOGETHER WITH RADIATION TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME Del Mar Pharmaceuticals (CA) 2017-09-20 EP disclosed
EP-2590938-B1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH WELICHEM BIOTECH INC (CA) 2017-06-07 EP disclosed
EP-2590938-B1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH WELICHEM BIOTECH INC (CA) 2017-06-07 EP disclosed
US-20170007627-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH WELICHEM BIOTECH INC. (CA) 2017-01-12 US disclosed
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US disclosed
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US disclosed
CN-103221388-A Novel sulfonamide compounds for inhibition of metastatic tumor growth METASIGNAL THERAPEUTICS INC 2013-07-24 CN disclosed
EP-2590938-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH Metasignal Therapeutics Inc. (CA) 2013-05-15 EP disclosed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO disclosed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO disclosed
CN-1330705-C Flame retardant aromatic poly cabonic ester resin composition and finished products TEIJIN CHEMICAL CO LTD (JP) 2007-08-08 CN disclosed
CN-1408767-A Flame retardant aromatic poly cabonic ester resin composition and finished products TEIJIN CHEMICAL CO LTD (JP) 2003-04-09 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH HIF1AN, CBX2, HIF1A CA2 5/4885CA1 31/4885CA12 61/4885
US-20190015379-A1 USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF, TOGETHER WITH RADIATION, TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME AND SUPPRESS PROLIFERATION OF CANCER STEM CELLS MGMT, DCLRE1A, DNMT1 CA2 4654/4885CA1 2097/4885CA12 1160/4885
US-20170007627-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH HIF1AN, CBX2, HIF1A CA2 5/4885CA1 31/4885CA12 61/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.