Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6718394 | 0.93 | PTGS2 (0.44) | PTGS2CCR2PTGS1PDE3A | |
| SCHEMBL6718610 | 0.91 | PTGS2 (0.48) | PTGS2ALDH1A1PTGS1PDE3A | |
| SCHEMBL6721628 | 0.91 | PTGS2 (0.46) | PTGS2PTGS1PDE3A | |
| SCHEMBL6721472 | 0.90 | PTGS2 (0.46) | PTGS2NPSR1MAPK1CCR2MCOLN3 | |
| SCHEMBL6726190 | 0.90 | PTGS2 (0.47) | PTGS2ALDH1A1PTGS1PDE3A | |
| SCHEMBL6721862 | 0.90 | PTGS2 (0.59) | PTGS2ALDH1A1PTGS1PDE3A | |
| SCHEMBL6730025 | 0.90 | PTGS2 (0.47) | PTGS2ALDH1A1PTGS1PDE3A | |
| SCHEMBL6721984 | 0.89 | PTGS2 (0.46) | PTGS2CCR2ALDH1A1PTGS1 | |
| SCHEMBL6725419 | 0.89 | PTGS2 (0.42) | PTGS2NPSR1PTGS1 | |
| SCHEMBL6718433 | 0.89 | PTGS2 (0.55) | PTGS2NPSR1MAPK1MCOLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040092552-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2004-05-13 | — | — | US | disclosed |
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2002-12-05 | — | — | US | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | FPR2, FPR1, PTGES2 | PTGS2 5/4885NPSR1 641/4885MAPK1 781/4885 |
| US-20040092552-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | FPR2, PTGES2, FPR1 | PTGS2 5/4885NPSR1 618/4885MAPK1 777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.