SCHEMBL672198

SCHEMBL672198

C[Si](C)(C)C#Cc1ccc(I)cc1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
APP P05067 3/20 0.36
GABRA1 P14867 2/20 0.34
GABRG2 P18507 2/20 0.34
GABRB3 P28472 2/20 0.34
GABRA5 P31644 2/20 0.34
GABRA3 P34903 2/20 0.34
GABRA2 P47869 2/20 0.34
HDAC8 Q9BY41 1/20 0.31
GRM5 P41594 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17319633 0.98 APP (0.35) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL16681847 0.98 APP (0.35) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL16681897 0.94 CYP1A1 (0.38) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL4107898 0.88 APP (0.41) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL10032993 0.88 APP (0.34) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL1306384 0.87 GABRA1 (0.38) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL2866650 0.85 ENPP2 (0.41) APP
SCHEMBL1306505 0.85 APP (0.41) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL2854252 0.80 CYP1A1 (0.44) APPGABRA1GABRG2GABRB3GABRA5
SCHEMBL19174201 0.78 CYP1A1 (0.48) APPGABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119774958-A Novel seepage-proofing mortar for back water wall surface and construction process thereof 保定禹建防水科技有限公司 2025-04-08 CN claimed
CN-119774958-B Novel seepage-proofing mortar for back water wall surface and construction process thereof 保定禹建防水科技有限公司 2025-09-26 CN disclosed
WO-2025076285-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME DELPHIA THERAPEUTICS, INC. (US) 2025-04-10 WO disclosed
CN-119774958-A Novel seepage-proofing mortar for back water wall surface and construction process thereof 保定禹建防水科技有限公司 2025-04-08 CN disclosed
CN-119774958-A Novel seepage-proofing mortar for back water wall surface and construction process thereof 保定禹建防水科技有限公司 2025-04-08 CN disclosed
CN-107531698-B Fused bicyclic heteroaryl derivatives having activity as PHD inhibitors 武田药品工业株式会社 2024-08-13 CN disclosed
CN-115210336-B Light absorbing material, recording medium using the same, information recording method, and information reading method 松下知识产权经营株式会社 2024-05-03 CN disclosed
CN-115745537-B Light plastering mortar and preparation method thereof 唐山盾石干粉建材有限责任公司 2024-01-02 CN disclosed
US-20230077155-A1 TETRAHYDROISOQUINOLINE COMPOUND AS POTASSIUM CHANNEL MODULATOR AND PREPARATION AND APPLICATION THEREOF SHANGHAI ZHIMENG BIOPHARMA, INC. (CN) 2023-03-09 US disclosed
CN-115745537-A Lightweight plastering mortar and preparation method thereof 唐山盾石干粉建材有限责任公司 2023-03-07 CN disclosed
WO-2001003126-A9 HIGH DENSITY NON-VOLATILE MEMORY DEVICE UNIV CALIFORNIA (US) 2002-08-01 WO disclosed
EP-1210714-A2 HIGH DENSITY NON-VOLATILE MEMORY DEVICE The Regents of the University of California (US) 2002-06-05 EP disclosed
US-6232062-B1 HYBRIDIZATION CLINICAL MICRO SENSORS, INC. 2001-05-15 US disclosed
US-6221583-B1 USE OF NUCLEIC ACIDS CONTAINING ELECTRON TRANSFER MOIETIES TO BE USED AS NUCLEIC ACID PROBES; PROBE NUCLEIC ACID IS COVALENTLY ATTACHED TO AN ELECTRODE VIA A CONDUCTIVE OLIGOMER CLINICAL MICRO SENSORS, INC. 2001-04-24 US disclosed
WO-2001003126-A2 HIGH DENSITY NON-VOLATILE MEMORY DEVICE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-01-11 WO disclosed
US-6096273-A SITE-SELECTIVE MODIFICATION OF NUCLEIC ACIDS WITH ELECTRON TRANSFER MOIETIES AND ELECTRODES, FOR GENE PROBES, MEDICAL DIAGNOSIS, TISSUE COMPATIBILITY EVALUATIONS BEFORE TRANSPLANTATION, FORENSICS CLINICAL MICRO SENSORS (US) 2000-08-01 US disclosed
US-6090933-A ATTACHING THE SULFUR OF A CONDUCTIVE OLIGOMER HAVING A FIRST SUBUNIT OF A SULFUR ATOM PROTECTED BY ETHYL PYRIDINE OR TRIMETHYLSILYL ETHYL, TO THE GOLD ELECTRODE; NUCLEIC ACIDS COVALENTLY COUPLED TO ELECTRODES VIA CONDUCTIVE OLIGOMERS CLINICAL MICRO SENSORS, INC. (US) 2000-07-18 US disclosed
US-6063573-A SINGLE-STRANDED PROBE FOR SCREENING TARGET NUCLEOTIDE SEQUENCES CLINICAL MICRO SENSORS, INC. (US) 2000-05-16 US disclosed
EP-0939762-A2 ELECTRODES LINKED VIA CONDUCTIVE OLIGOMERS TO NUCLEIC ACIDS Clinical Micro Sensors (US) 1999-09-08 EP disclosed
WO-1998020162-A2 ELECTRODES LINKED VIA CONDUCTIVE OLIGOMERS TO NUCLEIC ACIDS CLINICAL MICRO SENSORS (US) 1998-05-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230077155-A1 TETRAHYDROISOQUINOLINE COMPOUND AS POTASSIUM CHANNEL MODULATOR AND PREPARATION AND APPLICATION THEREOF KCNQ2, KCNQ1, KCNJ2 APP 545/4885GABRA1 216/4885GABRG2 234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.