SCHEMBL6722098

SCHEMBL6722098

COc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(S(N)(=O)=O)c(F)c2)cc1Cl

nearest known ligand 0.71

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 20/20 0.71
PTGS1 P23219 9/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6726119 0.93 PTGS2 (0.71) PTGS2PTGS1
SCHEMBL6722980 0.91 PTGS2 (0.59) PTGS2PTGS1
SCHEMBL6725853 0.88 PTGS2 (0.71) PTGS2PTGS1
SCHEMBL6721609 0.88 PTGS2 (0.61) PTGS2PTGS1
SCHEMBL6730001 0.87 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL8218509 0.87 PTGS2 (0.54) PTGS2PTGS1
SCHEMBL8035330 0.85 PTGS2 (0.76) PTGS2PTGS1
SCHEMBL6718462 0.85 PTGS2 (0.66) PTGS2PTGS1
SCHEMBL6340118 0.85 PTGS2 (0.82) PTGS2PTGS1
SCHEMBL6723617 0.85 PTGS2 (0.73) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092552-A1 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-05-13 US disclosed
US-20020183362-A1 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2002-12-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020183362-A1 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation FPR2, FPR1, PTGES2 PTGS2 5/4885PTGS1 4/4885
US-20040092552-A1 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation FPR2, PTGES2, FPR1 PTGS2 5/4885PTGS1 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.