Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707751 | 0.85 | CRHR1 (0.73) | CRHR1 | |
| SCHEMBL5246749 | 0.81 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL6726554 | 0.79 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL7076625 | 0.78 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL7081441 | 0.78 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL5250469 | 0.77 | CRHR1 (0.77) | CRHR1 | |
| SCHEMBL3365427 | 0.75 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL6831521 | 0.75 | CRHR1 (1.00) | CRHR1 | |
| Hydrochloric Acid SCHEMBL3367488 | 0.74 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL5599397 | 0.74 | CRHR1 (0.93) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040121998-A1 | CRF antagonistic quino- and quinazolines | NEUROCRINE BIOSCIENCES, INC. | 2004-06-24 | — | — | US | claimed |
| EP-0977737-B1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | claimed |
| US-20030119818-A1 | CRF antagonistic quino-and quinazolines | HUANG CHARLES (US) | 2003-06-26 | — | — | US | claimed |
| US-6482836-B1 | CRF antagonistic quino- and quinazolines | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-11-19 | — | — | US | claimed |
| EP-0977737-A1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | claimed |
| WO-1998047874-A1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-10-29 | — | — | WO | claimed |
| US-20040121998-A1 | CRF antagonistic quino- and quinazolines | NEUROCRINE BIOSCIENCES, INC. | 2004-06-24 | — | — | US | disclosed |
| US-6610678-B2 | Corticotropin-releasing factor antagonists; treating endocrine, psychiatric or neurologic disorders | HUANG CHARLES (US) | 2003-08-26 | — | — | US | disclosed |
| US-20030119818-A1 | CRF antagonistic quino-and quinazolines | HUANG CHARLES (US) | 2003-06-26 | — | — | US | disclosed |
| US-6482836-B1 | CRF antagonistic quino- and quinazolines | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-11-19 | — | — | US | disclosed |
| EP-0977737-A1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047874-A1 | CRF ANTAGONISTIC QUINO- AND QUINAZOLINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119818-A1 | CRF antagonistic quino-and quinazolines | CRHR1, HTR6, CRH | CRHR1 1/4885 |
| US-20040121998-A1 | CRF antagonistic quino- and quinazolines | CRHR1, HTR6, CRH | CRHR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.