Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | OGG1 | O15527 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340626 | 0.82 | PPARA (0.58) | CNR1POLBPPARACYP1A2CYP3A4 | |
| SCHEMBL1618680 | 0.82 | PPARG (0.44) | KDM4EPPARACYP1A2CYP3A4MEN1 | |
| SCHEMBL11264759 | 0.81 | KDM4E (0.47) | POLBKDM4EPPARAMAPTPPARG | |
| SCHEMBL7620864 | 0.78 | SMN1; SMN2 (0.44) | POLBCYP1A2MEN1MAPTCYP2C19 | |
| SCHEMBL17859584 | 0.77 | HSD11B1 (0.46) | CNR1CNR2POLBHSD11B1HSD11B2 | |
| SCHEMBL9588829 | 0.77 | HSD11B1 (0.49) | CNR1CNR2POLBHSD11B1HSD11B2 | |
| SCHEMBL3374117 | 0.77 | PPARA (0.64) | CNR1CNR2HSD11B1HSD11B2KDM4E | |
| SCHEMBL4422408 | 0.74 | PPARA (0.68) | CNR1CNR2POLBPPARACYP1A2 | |
| SCHEMBL9466283 | 0.74 | PPARA (0.41) | CNR1KDM4EPPARACYP1A2CYP3A4 | |
| SCHEMBL11259943 | 0.73 | OGG1 (0.56) | KDM4EOGG1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869794-B1 | SUBSTITUTED TETRAHYDROFURAN ANALOGS OF PROSTAGLANDINS AS OCULAR HYPOTENSIVES | ALCON LAB INC (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6369102-B2 | GLAUCOMA | ALCON MANUFACTURING, LTD. | 2002-04-09 | — | — | US | disclosed |
| US-20010029265-A1 | Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives | ALCON RESEARCH, LTD. | 2001-10-11 | — | — | US | disclosed |
| US-6235779-B1 | TOPICAL | ALCON LABORATORIES, INC. | 2001-05-22 | — | — | US | disclosed |
| US-6197812-B1 | SUBSTITUTED TETRAHYDROFURAN ANALOGS OF D AND F SERIES PROSTAGLANDINS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION. | ALCON LABORATORIES, INC. | 2001-03-06 | — | — | US | disclosed |
| US-6025392-A | substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives | ALCON LABORATORIES, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5994397-A | Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives | ALCON LABORATORIES, INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0944593-A2 | $i(CIS)-$g(D)?4 ANALOGS OF PROSTAGLANDINS AS OCULAR HYPOTENSIVES | ALCON LABORATORIES, INC. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998057942-A1 | 9-OXA PROSTAGLANDIN ANALOGS AS OCULAR HYPOTENSIVES | ALCON LABORATORIES, INC. (US) | 1998-12-23 | — | — | WO | disclosed |
| EP-0869794-A1 | SUBSTITUTED TETRAHYDROFURAN ANALOGS OF PROSTAGLANDINS AS OCULAR HYPOTENSIVES | ALCON LABORATORIES, INC. (US) | 1998-10-14 | — | — | EP | disclosed |
| US-5814660-A | TREATMENT OF GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1998-09-29 | — | — | US | disclosed |
| WO-1998021182-A2 | USE OF CIS-Δ4 ANALOGS OF PROSTAGLANDINS AS OCULAR HYPOTENSIVES | ALCON LABORATORIES, INC. (US) | 1998-05-22 | — | — | WO | disclosed |
| US-5665773-A | Cloprostenol and fluprostenol analogues and their use to treat glaucoma and ocular hypertension | ALCON LABORATORIES, INC. (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997023223-A1 | SUBSTITUTED TETRAHYDROFURAN ANALOGS OF PROSTAGLANDINS AS OCULAR HYPOTENSIVES | ALCON LABORATORIES, INC. (US) | 1997-07-03 | — | — | WO | disclosed |
| US-4346228-A | Novel 11-oxoprostaglandin derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-08-24 | — | — | US | disclosed |
| US-4306095-A | USEABLE IN LUTEOLYSIS, INHIBITING BLOOD PLATELET AGGREGATION AND INHIBITING PRODUCTION OF GASTRIC ACID | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-15 | — | — | US | disclosed |
| US-4241215-A | FOR LUTEOLYSIS, INHIBITING BLOOD PLATELET AGGREGATION, AND INHIBITING SECRETION OF GASTRIC JUICES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-23 | — | — | US | disclosed |
| US-4079145-A | PROSTAGLANDIN ANALOGUES; SPASMOLYTIC, HYPOTENSIVE, ANTISECRETORY AGENTS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010029265-A1 | Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives | PTGIS, PTGIR, PTGS1 | CNR1 463/4885CNR2 225/4885POLB 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.