SCHEMBL6722787

SCHEMBL6722787

Fc1cc(Cl)ccc1-c1ncnc(C(F)F)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMO O15229 2/20 0.43
KIT P10721 9/20 0.40
SIGMAR1 Q99720 1/20 0.40
EGLN2 Q96KS0 1/20 0.39
CLK1 P49759 1/20 0.35
MAPK14 Q16539 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA2B P29275 1/20 0.34
ADORA1 P30542 1/20 0.34
GABRA1 P14867 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
GABRA2 P47869 1/20 0.33
TGFBR1 P36897 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6727272 0.93 KIT (0.43) KMOKITSIGMAR1EGLN2
SCHEMBL6722947 0.88 KIT (0.41) KMOKITSIGMAR1MAPK14TGFBR1
SCHEMBL6727232 0.86 AHR (0.40) EGLN2
SCHEMBL6715763 0.78 KIT (0.45) KMOKITSIGMAR1EGLN2CLK1
SCHEMBL6719105 0.77 KCNH2 (0.33)
SCHEMBL6722700 0.77 KCNH2 (0.33) KIT
SCHEMBL6726979 0.76 KMO (0.43) KMOKITSIGMAR1EGLN2CLK1
SCHEMBL6722763 0.76 KIT (0.41) KMOKITSIGMAR1MAPK14
SCHEMBL6719107 0.74 KCNH2 (0.30)
SCHEMBL6715765 0.73 KCNH2 (0.39) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2004-05-13 US disclosed
CN-1473155-A Pyrimidine derivatives and herbicides containing the same ס������ũҩ��ʽ���� 2004-02-04 CN disclosed
EP-1333029-A1 PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME Sumitomo Chemical Takeda Agro Company, Limited (JP) 2003-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same DDX41, CBR3, DPYD KMO 2539/4885KIT 3365/4885SIGMAR1 1814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.