SCHEMBL6722979

SCHEMBL6722979

Nc1cc(-c2ncnc(C(F)(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.31

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.31
KIF5B P33176 1/20 0.31
KDR P35968 1/20 0.31
KCNH2 Q12809 1/20 0.31
CCDC6 Q16204 1/20 0.31
GAA P10253 1/20 0.31
CA2 P00918 1/20 0.30
CHKA P35790 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6722987 0.83 RECQL (0.32)
SCHEMBL6719174 0.83 KHK (0.38)
SCHEMBL6716002 0.80 EGFR (0.37) KDRKCNH2
SCHEMBL6719802 0.78 CYP3A4 (0.39) GAAALDH1A1SMN1; SMN2
SCHEMBL6722700 0.77 KCNH2 (0.33) RETKIF5BKDRKCNH2CCDC6
SCHEMBL6726979 0.77 KMO (0.43) KDM4EALDH1A1
SCHEMBL6722857 0.77 KIT (0.41)
SCHEMBL6716158 0.75 PGK1 (0.36)
SCHEMBL17408111 0.74 KDM1A (0.36) KDM4EALDH1A1POLBSMN1; SMN2
SCHEMBL6743960 0.74 KDM4E (0.33) KDM4EALDH1A1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2004-05-13 US disclosed
CN-1473155-A Pyrimidine derivatives and herbicides containing the same ס������ũҩ��ʽ���� 2004-02-04 CN disclosed
EP-1333029-A1 PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME Sumitomo Chemical Takeda Agro Company, Limited (JP) 2003-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092402-A1 Pyrimidine derivatives and herbicides containing the same DDX41, CBR3, DPYD RET 1433/4885KIF5B 3811/4885KDR 2164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.