Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727897 | 0.90 | ALDH1A1 (0.35) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL6734161 | 0.88 | LMNA (0.38) | LMNACYP3A4ALDH1A1CYP2C9HPGD | |
| SCHEMBL6549646 | 0.88 | CYP3A4 (0.39) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL6723707 | 0.88 | LMNA (0.39) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL6734521 | 0.87 | ALDH1A1 (0.37) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL6726465 | 0.87 | ALDH1A1 (0.38) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL6551068 | 0.86 | ALDH1A1 (0.39) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL6728044 | 0.86 | ALDH1A1 (0.39) | LMNACYP2D6TSHRALDH1A1CYP2C9 | |
| SCHEMBL6726409 | 0.84 | LMNA (0.36) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL6734431 | 0.84 | L3MBTL1 (0.39) | LMNACYP3A4CYP2D6MAPK1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224251-A1 | Positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-11-11 | — | — | US | disclosed |
| US-6548220-B2 | Containing acid generator | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-04-15 | — | — | US | disclosed |