Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.43 |
| ▸ | THRB | P10828 | 8/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PCNA | P12004 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042106 | 0.88 | FFAR1 (0.54) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4271148 | 0.87 | THRA (0.57) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4276277 | 0.79 | THRA (0.47) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4265967 | 0.77 | F2 (0.49) | IDO1F2 | |
| SCHEMBL4931492 | 0.77 | THRA (0.46) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL24991401 | 0.75 | IDO1 (0.47) | IDO1TDP1 | |
| SCHEMBL4269700 | 0.75 | FFAR1 (0.70) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4898421 | 0.74 | THRA (0.77) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4272376 | 0.74 | THRA (0.77) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL6721162 | 0.74 | F2 (0.46) | THRATHRBPGRIDO1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| US-6638977-B1 | Biaryl and benzyl ethers and thioethers | CORVAS INTERNATIONAL, INC. | 2003-10-28 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |