Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | HTR1F | P30939 | 4/20 | 0.44 |
| ▸ | HTR1B | P28222 | 3/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6724794 | 0.95 | MET (0.53) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6734018 | 0.94 | MET (0.51) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6724792 | 0.93 | HTR1A (0.49) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6726989 | 0.92 | TEC (0.44) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6726991 | 0.88 | HTR1A (0.48) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6733766 | 0.88 | MET (0.46) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6724797 | 0.85 | KDM4E (0.46) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6722238 | 0.85 | HTR1A (0.47) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6722076 | 0.85 | MEN1 (0.42) | METHTR1AHTR1FHTR1BHTR1D | |
| SCHEMBL6722035 | 0.84 | HTR2C (0.44) | HTR1AHTR1FHTR1BHTR1DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |