Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.49 |
| ▸ | HTR1F | P30939 | 10/20 | 0.49 |
| ▸ | HTR1D | P28221 | 8/20 | 0.49 |
| ▸ | HTR1B | P28222 | 7/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726991 | 0.96 | HTR1A (0.48) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6724701 | 0.93 | MET (0.48) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6726989 | 0.90 | TEC (0.44) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6734018 | 0.88 | MET (0.51) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6724794 | 0.88 | MET (0.53) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6733766 | 0.86 | MET (0.46) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6724813 | 0.84 | HTR1A (0.55) | HTR1AHTR1FHTR1DHTR1BPIM1 | |
| SCHEMBL6722238 | 0.83 | HTR1A (0.47) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6722076 | 0.83 | MEN1 (0.42) | HTR1AHTR1FHTR1DHTR1BMET | |
| SCHEMBL6722139 | 0.83 | RXFP1 (0.54) | HTR1AHTR1FHTR1DHTR1BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | claimed |
| US-6673811-B1 | TREATMENT OF ANXIETY, DEPRESSION, SLEEP DISORDER, ATTENTION DEFICIT DISORDER, ALZHEIMER'S DEMENTIA, OR SHORT-TERM MEMORY LOSS | NEUROGEN CORPORATION | 2004-01-06 | — | — | US | disclosed |