Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.57 |
| ▸ | THRB | P10828 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CD69 | Q07108 | 5/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6725180 | 0.93 | THRB (0.55) | THRATHRBKMT2ACD69ELANE | |
| SCHEMBL6728497 | 0.92 | THRA (0.61) | THRATHRBKMT2ACD69ALOX15 | |
| SCHEMBL14040248 | 0.84 | THRA (0.46) | THRATHRBKMT2ACD69ELANE | |
| SCHEMBL6720881 | 0.82 | THRB (0.49) | THRATHRBKMT2ACD69ELANE | |
| SCHEMBL22359890 | 0.81 | THRA (0.50) | THRATHRBKMT2ACD69ELANE | |
| SCHEMBL11426652 | 0.81 | THRA (0.51) | THRATHRBKMT2ACD69KDM4E | |
| SCHEMBL31619991 | 0.78 | GAA (0.44) | THRATHRBKMT2ATPMTBPTF | |
| SCHEMBL8729041 | 0.77 | THRA (0.61) | THRATHRBKMT2AALOX15 | |
| SCHEMBL5276461 | 0.77 | TSHR (0.49) | THRATHRBCD69ELANE | |
| SCHEMBL2113590 | 0.77 | PTGDR2 (0.46) | THRATHRBKMT2ACD69ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |