Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SLC26A3 | P40879 | 5/20 | 0.39 |
| ▸ | TTPA | P49638 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6597291 | 0.88 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL4592776 | 0.88 | PSEN1 (0.65) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL6732328 | 0.82 | PSEN1 (0.60) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL2140140 | 0.79 | PSEN1 (0.53) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL2140130 | 0.79 | PSEN1 (0.53) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL11701054 | 0.79 | PSEN1 (0.56) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL10074168 | 0.76 | PSEN1 (0.69) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL9257213 | 0.75 | PSEN1 (0.67) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL8421050 | 0.74 | PSEN1 (0.58) | PSEN1PTGS1PTGS2CYP1A2CYP3A4 | |
| SCHEMBL10535389 | 0.74 | PSEN1 (0.43) | PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |