Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6731839 | 0.86 | ALDH1A1 (0.51) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL6723594 | 0.83 | FFAR1 (0.47) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL4889995 | 0.82 | THRA (0.72) | THRATHRBFFAR4FFAR1PTGER1 | |
| SCHEMBL6724842 | 0.80 | PARP10 (0.51) | THRATHRBFFAR1NR1H4NR4A2 | |
| SCHEMBL29108936 | 0.79 | THRA (0.66) | THRATHRBNR1H4NR4A2KMT2A | |
| SCHEMBL6238338 | 0.77 | FFAR1 (0.66) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL6238855 | 0.76 | NR4A2 (0.68) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL8405616 | 0.74 | FFAR4 (0.45) | FFAR4FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL4273222 | 0.73 | ALDH1A1 (0.54) | THRATHRBFFAR4FFAR1NR4A2 | |
| SCHEMBL4887098 | 0.71 | THRA (0.69) | THRATHRBFFAR4FFAR1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | claimed |
| US-20040248099-A1 | Use of intermediate -conductance potassium channels and modulators for diagnosing and treating diseases having disturbed keratinocyte activity | SWITCH BIOTECH AKTIENGESELLSCHAFT (DE) | 2004-12-09 | — | — | US | disclosed |
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |