Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.58 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265055 | 0.80 | MRGPRX4 (0.64) | MRGPRX4NR4A2MEN1KMT2ATP53 | |
| SCHEMBL4267556 | 0.80 | NR4A2 (0.64) | MRGPRX4NR4A2MEN1KMT2A | |
| SCHEMBL4280685 | 0.79 | MRGPRX4 (0.60) | MRGPRX4NR4A2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4269670 | 0.79 | MEN1 (0.63) | NR4A2MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL6725090 | 0.77 | ALKBH1 (0.46) | MRGPRX4NR4A2MEN1KMT2A | |
| SCHEMBL4265967 | 0.77 | F2 (0.49) | MRGPRX4NR4A2MEN1KMT2ATP53 | |
| SCHEMBL6724979 | 0.76 | SRD5A2 (0.58) | MRGPRX4NR4A2MEN1KMT2ANPC1 | |
| SCHEMBL6725244 | 0.76 | MAOB (0.49) | MRGPRX4LPAR1LPAR5 | |
| SCHEMBL6720945 | 0.75 | NR4A2 (0.59) | NR4A2MEN1KMT2A | |
| SCHEMBL27824670 | 0.75 | AKR1C3 (0.67) | MRGPRX4LPAR1LPAR5NR4A2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | claimed |
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |