Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.59 |
| ▸ | PPARA | Q07869 | 7/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265171 | 0.88 | RXRA (0.62) | NR4A2PPARARXRARXRBMEN1 | |
| SCHEMBL4269670 | 0.86 | MEN1 (0.63) | NR4A2RXRARXRBMEN1KMT2A | |
| SCHEMBL6731785 | 0.85 | NR4A2 (0.59) | NR4A2PPARARXRARXRBKDM5A | |
| SCHEMBL4274343 | 0.85 | RXRA (0.59) | PPARARXRARXRBKDM5AKDM5B | |
| SCHEMBL4278599 | 0.85 | THRA (0.50) | RXRARXRBKDM5AKDM2BKDM4C | |
| SCHEMBL6725141 | 0.84 | RXRA (0.55) | NR4A2PPARARXRARXRBKDM5A | |
| SCHEMBL4267556 | 0.84 | NR4A2 (0.64) | NR4A2PPARAKDM5AKDM5BMAOB | |
| SCHEMBL17916639 | 0.83 | NR4A2 (0.60) | NR4A2PPARARXRARXRBKMT2A | |
| SCHEMBL6725214 | 0.82 | MRGPRX4 (0.57) | NR4A2PPARARXRARXRBMEN1 | |
| SCHEMBL29319558 | 0.81 | RXRA (0.62) | NR4A2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |