Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6729970 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1SCN9A | |
| SCHEMBL6734732 | 0.87 | PTGS2 (0.44) | PTGS2PIM1PIM2PTGS1KCNH2 | |
| SCHEMBL7537753 | 0.82 | RPS6KA3 (0.51) | PIM1PIM2DHODHNR1H2NR1H3 | |
| SCHEMBL6721924 | 0.82 | ALOX5AP (0.46) | PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL7541582 | 0.81 | DHODH (0.43) | PTGS2PIM1PIM2PTGS1KCNH2 | |
| SCHEMBL6718753 | 0.81 | PTGS2 (0.48) | PTGS2PTGS1DHODH | |
| SCHEMBL6722775 | 0.81 | PTGS2 (0.51) | PTGS2PTGS1SCN9A | |
| SCHEMBL7546443 | 0.81 | PTGS2 (0.48) | PTGS2PIM1PIM2PTGS1PTGES2 | |
| SCHEMBL6725999 | 0.81 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL6723701 | 0.81 | PTGS2 (0.60) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040092552-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2004-05-13 | — | — | US | disclosed |
| US-20030232996-A1 | Regioselective synthesis of 3,4-di{(carboclyl or heterocyclyl)thiophenes | PHARMACIA CORPORATION | 2003-12-18 | — | — | US | disclosed |
| US-6600052-B1 | With a ring cyclizing reagent to form the compound of Formula V to yield a compound of Formula V: inhibitors of the cyclooxygenase- II enzyme. and antiinflammatory agents and analgesic pharmaceutical agents. | PHARMACIA CORPORATION | 2003-07-29 | — | — | US | disclosed |
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1276736-A2 | REGIOSELECTIVE SYNTHESIS OF 3,4-DI(CARBOCYCLYL OR HETEROCYCLYL)THIOPHENES | Pharmacia Corporation (US) | 2003-01-22 | — | — | EP | disclosed |
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2002-12-05 | — | — | US | disclosed |
| WO-2001081333-A2 | REGIOSELECTIVE SYNTHESIS OF 3,4-DI(CARBOCYCLYL OR HETEROCYCLYL)THIOPHENES | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | FPR2, FPR1, PTGES2 | PTGS2 5/4885PIM1 2964/4885PIM2 1970/4885 |
| US-20030232996-A1 | Regioselective synthesis of 3,4-di{(carboclyl or heterocyclyl)thiophenes | CCNE2, CCNC, CYP3A4 | PTGS2 784/4885PIM1 2098/4885PIM2 956/4885 |
| US-20040092552-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | FPR2, PTGES2, FPR1 | PTGS2 5/4885PIM1 3179/4885PIM2 2141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.