Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727065 | 0.87 | MAPT (0.49) | MAPTALOX15CXCR2ALDH1A1CFTR | |
| SCHEMBL4545983 | 0.83 | MAPT (0.49) | MAPTALOX15CXCR2ALDH1A1CFTR | |
| SCHEMBL24455292 | 0.81 | ALOX15 (0.43) | MAPTALOX15CXCR2ALDH1A1CFTR | |
| SCHEMBL29687400 | 0.81 | ALOX15 (0.43) | MAPTALOX15CXCR2ALDH1A1CFTR | |
| SCHEMBL1040683 | 0.77 | MEN1 (0.43) | MAPTALOX15CXCR2ALDH1A1MEN1 | |
| SCHEMBL30746848 | 0.77 | MEN1 (0.43) | MAPTALOX15CXCR2ALDH1A1MEN1 | |
| SCHEMBL31366874 | 0.77 | MAPT (0.48) | MAPTALOX15CXCR2ALDH1A1MEN1 | |
| SCHEMBL31366873 | 0.74 | MAPT (0.48) | MAPTALOX15CXCR2ALDH1A1CFTR | |
| SCHEMBL5740305 | 0.74 | MEN1 (0.41) | MAPTALOX15CXCR2ALDH1A1MEN1 | |
| SCHEMBL31366880 | 0.72 | MAPT (0.54) | MAPTALOX15CXCR2ALDH1A1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904481-B1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC (US) | 2016-02-17 | — | — | EP | disclosed |
| US-9024040-B2 | Processes for preparing benzimidazole compounds | ARRAY BIOPHARMA INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20130245279-A1 | PROCESSES FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ALEXION PHARMA INTERNATIONAL OPERATIONS LIMITED (IE) | 2013-09-19 | — | — | US | disclosed |
| US-8501956-B2 | Benzimidazole compounds | ARRAY BIOPHARMA INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8383832-B2 | Process for preparing benzimidazole compounds | ARRAY BIOPHARMA INC. (US) | 2013-02-26 | — | — | US | disclosed |
| US-8183385-B2 | SNAR process for preparing benzimidazole compounds | ARRAY BIOPHARMA INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183385-B2 | SNAR process for preparing benzimidazole compounds | ARRAY BIOPHARMA INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110319631-A1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319632-A1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-8039637-B2 | Process for preparing benzimidazole compounds | ARRAY BIOPHARMA INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039637-B2 | Process for preparing benzimidazole compounds | ARRAY BIOPHARMA INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100145065-A1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100145065-A1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100130748-A1 | SNAR PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130748-A1 | SNAR PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2007002157-A2 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002092-A1 | SNAr PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130748-A1 | SNAR PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | SMARCC2, C1R, SMARCC1 | MAPT 4306/4885ALOX15 4402/4885CXCR2 1368/4885 |
| US-20110319632-A1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | CYP3A5, H1-5, CYP3A4 | MAPT 4177/4885ALOX15 4243/4885CXCR2 2789/4885 |
| US-20100145065-A1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | CYP2E1, CYP1A1, F12 | MAPT 4485/4885ALOX15 3335/4885CXCR2 2438/4885 |
| US-20130245279-A1 | PROCESSES FOR PREPARING BENZIMIDAZOLE COMPOUNDS | TBCB, UQCRB, CYP3A5 | MAPT 3969/4885ALOX15 4060/4885CXCR2 2581/4885 |
| US-20110319631-A1 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS | CYP1B1, CCNB1, F12 | MAPT 4487/4885ALOX15 2997/4885CXCR2 1846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.