Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | FABP4 | P15090 | 3/20 | 0.52 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6725945 | 0.87 | TPMT (0.44) | NR4A2NPC1RAB9ANR4A1NR4A3 | |
| SCHEMBL6725244 | 0.83 | MAOB (0.49) | MAOBALKBH1GCK | |
| SCHEMBL4273058 | 0.83 | THRA (0.51) | NR4A2NPC1RAB9AMAOBMEN1 | |
| SCHEMBL4273222 | 0.83 | ALDH1A1 (0.54) | NR4A2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6723594 | 0.82 | FFAR1 (0.47) | MCL1KMT2ARXRARXRBFFAR1 | |
| SCHEMBL1263196 | 0.81 | NR4A2 (0.78) | NR4A2NPC1RAB9AFABP4FABP5 | |
| SCHEMBL12432458 | 0.81 | HDAC8 (0.59) | NR4A2NPC1RAB9AFABP4FABP5 | |
| SCHEMBL4269670 | 0.80 | MEN1 (0.63) | NR4A2NR4A1NR4A3MEN1KMT2A | |
| SCHEMBL6726446 | 0.80 | MAOB (0.52) | MAOAMAOBRXRARXRBFFAR1 | |
| SCHEMBL4268890 | 0.80 | ALKBH1 (0.50) | NR4A2NPC1RAB9AMAOBALKBH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | claimed |
| US-6677473-B1 | TREATMENT, PREVENTION OR AMELIORATION OF ONE OR MORE SYMPTOMS OF THROMBOTIC DISORDERS, UNSTABLE ANGINA OR CANCER | CORVAS INTERNATIONAL INC | 2004-01-13 | — | — | US | disclosed |
| WO-2003009871-A2 | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR FOR DECREASING BODY MASS | GENSET S.A. (FR) | 2003-02-06 | — | — | WO | disclosed |
| WO-2001036351-A2 | PLASMINOGEN ACTIVATOR INHIBITOR ANTAGONISTS RELATED APPLICATIONS | CORVAS INTERNATIONAL, INC. (US) | 2001-05-25 | — | — | WO | disclosed |