Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 8/20 | 0.36 |
| ▸ | MMP9 | P14780 | 8/20 | 0.36 |
| ▸ | MMP1 | P03956 | 5/20 | 0.36 |
| ▸ | MMP13 | P45452 | 5/20 | 0.36 |
| ▸ | MMP3 | P08254 | 4/20 | 0.36 |
| ▸ | MMP14 | P50281 | 4/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MMP16 | P51512 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723622 | 0.88 | DUT (0.51) | DUTLMNAALDH1A1MEN1TSHR | |
| SCHEMBL6719216 | 0.85 | MMP2 (0.49) | DUTLMNAMMP2MMP9MMP1 | |
| SCHEMBL6719833 | 0.81 | MMP2 (0.41) | LMNAALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL6722425 | 0.81 | LMNA (0.46) | DUTLMNAMMP2MMP9MMP1 | |
| SCHEMBL6722457 | 0.80 | LMNA (0.45) | DUTLMNAMMP2MMP9MMP1 | |
| SCHEMBL7847823 | 0.79 | DUT (0.46) | DUTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6722549 | 0.74 | DUT (0.43) | DUTLMNATSHR | |
| SCHEMBL6724062 | 0.74 | DUT (0.40) | DUTALDH1A1MMP2MMP9MMP1 | |
| SCHEMBL6724128 | 0.72 | MMP2 (0.45) | DUTMMP2MMP9MMP1MMP13 | |
| SCHEMBL6722473 | 0.72 | MMP2 (0.55) | DUTLMNAMMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |