Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 4/20 | 0.73 |
| ▸ | TTR | P02766 | 3/20 | 0.72 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 4/20 | 0.60 |
| ▸ | THRA | P10827 | 3/20 | 0.60 |
| ▸ | KDM5A | P29375 | 7/20 | 0.57 |
| ▸ | KDM4A | O75164 | 3/20 | 0.57 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6735773 | 0.88 | CYP2C19 (0.71) | EYA3TTRPTPN1THRBCYP2C9 | |
| SCHEMBL6335384 | 0.85 | EYA3 (1.00) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL11847986 | 0.85 | EYA3 (0.78) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL25389924 | 0.84 | EYA3 (0.82) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL1287644 | 0.84 | TTR (1.00) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL11843232 | 0.84 | EYA3 (0.77) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL6735613 | 0.83 | EYA3 (0.63) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL27992957 | 0.83 | EYA3 (0.80) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL9195719 | 0.82 | EYA3 (0.73) | EYA3TTRPTPN1THRBTHRA | |
| SCHEMBL21447553 | 0.81 | EYA3 (0.80) | EYA3TTRPTPN1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683107-B2 | THERAPY OF METABOLISM DISORDERS | WYETH | 2004-01-27 | — | — | US | disclosed |
| US-20030073709-A1 | Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2003-04-17 | — | — | US | disclosed |
| US-6451845-B1 | ANTIDIABETIC AGENTS | WYETH | 2002-09-17 | — | — | US | disclosed |
| US-20020035272-A1 | Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-21 | — | — | US | disclosed |
| US-6248764-B1 | ANTIDIABETIC AGENT; HYPOGLYCEMIC AGENT | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-19 | — | — | US | disclosed |
| US-6103708-A | USEFUL IN TREATING METABOLIC DISORDERS RELATED TO INSULIN RESISTANCE OR HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073709-A1 | Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, FFAR3 | EYA3 3536/4885TTR 416/4885PTPN1 178/4885 |
| US-20020035272-A1 | Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia | INSR, GPR119, FFAR3 | EYA3 3483/4885TTR 507/4885PTPN1 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.