Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 8/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.62 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265011 | 0.86 | CYP3A4 (0.48) | CYP2C19CYP3A4CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL19312422 | 0.82 | LTA4H (0.60) | CYP2C19CYP3A4CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL10558040 | 0.80 | KIF11 (0.62) | CYP2C19CYP3A4CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL6727909 | 0.79 | MAPK1 (0.70) | LTA4HMEN1MAPTPABPC1KMT2A | |
| SCHEMBL6733124 | 0.79 | MAPT (0.59) | CYP2C19CYP3A4CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL13766316 | 0.77 | LTA4H (0.66) | CYP2D6CYP1A2LTA4HMEN1MAPT | |
| SCHEMBL3282376 | 0.77 | MAPK14 (0.59) | KDM5AKDM4CKDM5B | |
| SCHEMBL19967202 | 0.77 | LMNA (0.43) | CYP2C19CYP3A4CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL6732917 | 0.76 | LTA4H (0.56) | CYP2C19CYP3A4CYP2C9CYP2D6CYP1A2 | |
| SCHEMBL6731979 | 0.76 | LTA4H (0.56) | CYP2C19CYP3A4CYP2D6CYP1A2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800651-B2 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-10-05 | — | — | US | disclosed |
| US-20040006114-A1 | Potentiators of glutamate receptors | ELI LILLY AND COMPANY | 2004-01-08 | — | — | US | disclosed |
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006114-A1 | Potentiators of glutamate receptors | GRM1, GRIN1, GRM2 | CYP2C19 2053/4885CYP3A4 2786/4885CYP2C9 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.