Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10556645 | 0.81 | MAPT (0.41) | MEN1KMT2AALDH1A1POLBTSHR | |
| SCHEMBL15111121 | 0.80 | RAD51 (0.33) | MEN1KMT2ARAD51 | |
| SCHEMBL8691974 | 0.73 | ALDH1A1 (0.33) | MEN1KMT2AALDH1A1L3MBTL1KDM4E | |
| SCHEMBL15110957 | 0.72 | NR1H2 (0.48) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL9726295 | 0.72 | MAPK1 (0.31) | MAPK1 | |
| SCHEMBL22653501 | 0.71 | HPGD (0.41) | MEN1KMT2APOLBL3MBTL1KDM4E | |
| SCHEMBL9726384 | 0.71 | KDM5B (0.36) | KDM4ENPSR1MAPT | |
| SCHEMBL15111303 | 0.70 | RAD51 (0.33) | RAD51 | |
| SCHEMBL20594705 | 0.70 | ELANE (0.36) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL10674174 | 0.70 | GAA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | LEE LEN F (US) | 2004-11-04 | — | — | US | disclosed |
| US-6794396-B2 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-09-21 | — | — | US | disclosed |
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | PHARMACIA CORPORATION | 2004-02-26 | — | — | US | disclosed |
| WO-1999041237-A1 | SUBSTITUTED PYRIDINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | G.D. SEARLE & CO. (US) | 1999-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038939-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, CES1, MTTP | PPARA 2839/4885MEN1 3554/4885KMT2A 4198/4885 |
| US-20040220231-A1 | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity | CETP, MTTP, LCAT | PPARA 2665/4885MEN1 3895/4885KMT2A 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.