Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
| ▸ | GABRE | P78334 | 1/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30979681 | 0.91 | KMT2A (0.42) | CYP1A2LMNAGABRA1GABRB2GABRA2 | |
| SCHEMBL20094452 | 0.91 | CYP1A2 (0.41) | CYP1A2LMNAGABRA1GABRB2GABRA2 | |
| SCHEMBL12410988 | 0.86 | SMN1; SMN2 (0.47) | CYP1A2LMNAGABRA1GABRB2GABRA2 | |
| SCHEMBL9941672 | 0.86 | CYP1A2 (0.45) | CYP1A2GABRA1GABRB2GABRA2GABRP | |
| SCHEMBL24687926 | 0.85 | CYP1A2 (0.40) | CYP1A2LMNAGABRA1GABRB2GABRA2 | |
| SCHEMBL5208277 | 0.84 | CYP1A2 (0.44) | CYP1A2GABRA1GABRB2GABRA2GABRP | |
| SCHEMBL25435175 | 0.84 | ALDH1A1 (0.41) | CYP1A2LMNAGABRA1GABRB2GABRA2 | |
| SCHEMBL23754103 | 0.83 | TSHR (0.40) | CYP1A2LMNAGABRA1GABRB2GABRA2 | |
| SCHEMBL25033914 | 0.83 | ADORA3 (0.43) | CYP1A2LMNAGABRA1GABRB2GABRA2 | |
| SCHEMBL21244231 | 0.83 | CYP1A2 (0.42) | CYP1A2GABRA1GABRB2GABRA2GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3529247-B1 | HETEROCYCLIC FXR MODULATORS | HEPAGENE THERAPEUTICS HK LTD (HK) | 2021-08-18 | — | — | EP | disclosed |
| EP-3529247-B1 | HETEROCYCLIC FXR MODULATORS | HEPAGENE THERAPEUTICS HK LTD (HK) | 2021-08-18 | — | — | EP | disclosed |
| US-10899723-B2 | Heterocyclic containing cyclopropyl FXR modulators | Hepagene Therapeutics (HK) Limited (HK) | 2021-01-26 | — | — | US | disclosed |
| US-20190248752-A1 | HETEROCYCLIC FXR MODULATORS | Hepagene Therapeutics (HK) Limited (HK) | 2019-08-15 | — | — | US | disclosed |
| US-20190248752-A1 | HETEROCYCLIC FXR MODULATORS | Hepagene Therapeutics (HK) Limited (HK) | 2019-08-15 | — | — | US | disclosed |
| WO-2018075207-A1 | HETEROCYCLIC FXR MODULATORS | HEPAGENE THERAPEUTICS, INC. (VG) | 2018-04-26 | — | — | WO | disclosed |
| US-20040127507-A1 | Imidazolidine compounds | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-01 | — | — | US | disclosed |
| US-20040122026-A1 | Imidazolidine compounds | MILLENNIUM PHARMACEUTICALS, INC. | 2004-06-24 | — | — | US | disclosed |
| US-20030225288-A1 | Imidazolidine compounds | MILLENNIUM PHARMACEUTICALS, INC. | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10899723-B2 | Heterocyclic containing cyclopropyl FXR modulators | NR1H4, FXR1, GPBAR1 | CYP1A2 284/4885LMNA 3987/4885GABRA1 1879/4885 |
| US-20040127507-A1 | Imidazolidine compounds | IRAK1, IRAK4, IRAK2 | CYP1A2 270/4885LMNA 4169/4885GABRA1 1952/4885 |
| US-20190248752-A1 | HETEROCYCLIC FXR MODULATORS | NR1H4, FXR1, NR1H2 | CYP1A2 409/4885LMNA 4029/4885GABRA1 2186/4885 |
| US-20030225288-A1 | Imidazolidine compounds | IRAK1, IRAK4, IRAK2 | CYP1A2 270/4885LMNA 4169/4885GABRA1 1952/4885 |
| US-20040122026-A1 | Imidazolidine compounds | IRAK1, IRAK4, IRAK2 | CYP1A2 270/4885LMNA 4169/4885GABRA1 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.