Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 9/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.40 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17053175 | 0.85 | WNT3A (0.48) | WNT3APIK3CBHSD17B1HSD17B2PSEN1 | |
| SCHEMBL6737360 | 0.84 | WNT3A (0.47) | WNT3APIK3CBHSD17B1HSD17B2PSEN1 | |
| Lithium Ion SCHEMBL742465 | 0.80 | ROCK1 (0.44) | HSD17B1HSD17B2 | |
| Lithium Ion SCHEMBL12495952 | 0.79 | HSD17B1 (0.62) | HSD17B1HSD17B2 | |
| Lithium Ion SCHEMBL16102042 | 0.74 | ERCC5 (0.55) | HSD17B1HSD17B2 | |
| Lithium Ion SCHEMBL6737462 | 0.74 | MKNK1 (0.50) | CYP2D6 | |
| SCHEMBL30527101 | 0.73 | BACE1 (0.47) | WNT3APIK3CBDYRK1A | |
| Potassium Ion SCHEMBL4975200 | 0.71 | ERCC5 (0.55) | HSD17B1HSD17B2 | |
| Lithium Ion SCHEMBL5542954 | 0.71 | CES1 (0.53) | — | |
| SCHEMBL16896526 | 0.70 | KDM4E (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6747023-B1 | INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-06-08 | — | — | US | disclosed |
| US-20040082611-A1 | Anticoagulants; brain disorders; respiratory system disorders; side effect reduction | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1104754-A1 | NOVEL SULFONYL DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082611-A1 | Anticoagulants; brain disorders; respiratory system disorders; side effect reduction | F2, CYC1, SULT2A1 | WNT3A 3481/4885PIK3CB 3678/4885HSD17B1 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.