Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.30 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.30 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089632 | 0.78 | HSD17B10 (0.44) | LMNATSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL4410704 | 0.75 | PDGFRB (0.43) | TSHRKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL7124274 | 0.74 | HTT (0.43) | TSHRKMT2AALOX15ALDH1A1GAA | |
| SCHEMBL6220131 | 0.72 | MEN1 (0.46) | LMNATSHRKMT2AALOX15MEN1 | |
| SCHEMBL5410132 | 0.68 | POLB (0.53) | LMNATSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL6092642 | 0.67 | ALOX15 (0.42) | KMT2AALOX15MEN1ALDH1A1POLB | |
| SCHEMBL5403365 | 0.67 | TSHR (0.58) | TSHRKMT2AALOX15MEN1ALDH1A1 | |
| SCHEMBL5358334 | 0.66 | ALDH1A1 (0.39) | LMNAKMT2AALOX15MEN1ALDH1A1 | |
| SCHEMBL7117376 | 0.66 | ALDH1A1 (0.34) | KMT2AMEN1ALDH1A1POLBGAA | |
| SCHEMBL13195269 | 0.66 | TSHR (0.56) | TSHRKMT2AALOX15MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |