Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83317 | 0.84 | TDP1 (0.61) | TDP1SMN1; SMN2GPR35TSHRALDH1A1 | |
| SCHEMBL24548 | 0.78 | TDP1 (0.60) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| SCHEMBL29448254 | 0.78 | TDP1 (0.60) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| SCHEMBL10381945 | 0.78 | PDE7A (0.62) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| 2-Nitroaniline SCHEMBL6000 | 0.78 | PDE7A (0.62) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| 2-Nitroaniline SCHEMBL29396517 | 0.78 | PDE7A (0.62) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| SCHEMBL1913575 | 0.78 | ALDH1A1 (0.52) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| SCHEMBL32674585 | 0.78 | ALDH1A1 (0.52) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| SCHEMBL17934 | 0.77 | TSHR (0.59) | TDP1SMN1; SMN2PDE7AGPR35TSHR | |
| SCHEMBL9141067 | 0.76 | ERN1 (0.49) | TDP1SMN1; SMN2PDE7AGPR35TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102918044-A | Fused quinazoline derivatives and uses thereof | SHENZHEN SALUBRIS PHARM CO LTD | 2013-02-06 | — | — | CN | disclosed |
| US-6689771-B2 | TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS, CORNEAL ULCERATION, SOLID TUMOR GROWTH | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-02-10 | — | — | US | disclosed |
| US-6376665-B1 | ANTIARTHRITIC AGENTS, ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-04-23 | — | — | US | disclosed |
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |