Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | DDO | Q99489 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27452535 | 0.86 | LMNA (0.46) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL686904 | 0.85 | KMT2A (0.40) | MEN1KMT2AHTTGFERHSD17B10 | |
| SCHEMBL22556883 | 0.78 | KMT2A (0.42) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL28347900 | 0.77 | SIRT2 (0.53) | MEN1KMT2AHTTGFERHSD17B10 | |
| SCHEMBL1552646 | 0.76 | CYP19A1 (0.43) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL7759797 | 0.76 | CYP19A1 (0.39) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL486311 | 0.76 | MAPT (0.55) | KMT2A | |
| SCHEMBL9649335 | 0.76 | HCAR2 (0.52) | — | |
| SCHEMBL5674900 | 0.76 | POLB (0.52) | HTT | |
| SCHEMBL10529454 | 0.72 | MKNK1 (0.51) | MEN1KMT2AHTTGFERHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606042-B1 | DISUBSTITUTED TETRAHYDROFURANYL COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2014-09-03 | — | — | EP | disclosed |
| EP-2606042-A1 | DISUBSTITUTED TETRAHYDOFURANYL COMPOUNDS AS ANTAGONISTS OF THE BRADYKININ B1 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022795-A1 | DISUBSTITUTED TETRAHYDOFURANYL COMPOUNDS AS ANTAGONISTS OF THE BRADYKININ B1 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |