Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | DDO | Q99489 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26698243 | 0.81 | ACHE (0.44) | KMT2ASMN1; SMN2ESR1HIF1ARECQL | |
| SCHEMBL29852346 | 0.81 | ACHE (0.44) | KMT2ASMN1; SMN2ESR1HIF1ARECQL | |
| SCHEMBL22031512 | 0.81 | KMT2A (0.43) | KMT2ASMN1; SMN2ESR1HIF1ARECQL | |
| SCHEMBL27452535 | 0.80 | LMNA (0.46) | KMT2ASMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL13720620 | 0.80 | KMT2A (0.48) | KMT2ASMN1; SMN2ESR1HIF1ARECQL | |
| SCHEMBL27832542 | 0.79 | MAPT (0.50) | KMT2AMAPT | |
| SCHEMBL27689512 | 0.79 | POLB (0.46) | KDM4E | |
| SCHEMBL27562211 | 0.78 | CHRNB1 (0.47) | KMT2ASMN1; SMN2LMNAMEN1ACHE | |
| SCHEMBL674112 | 0.78 | MEN1 (0.52) | KMT2ALMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL27520799 | 0.74 | ELANE (0.49) | KMT2ASMN1; SMN2ESR1HIF1ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |