SCHEMBL6741209

SCHEMBL6741209

Cc1ccc([Mg]Br)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 5/20 0.36
ACHE P22303 4/20 0.35
CYP2A6 P11509 3/20 0.35
CYP1A2 P05177 2/20 0.35
TDP1 Q9NUW8 5/20 0.31
TP53 P04637 2/20 0.31
CYP3A4 P08684 1/20 0.31
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TRPA1 O75762 1/20 0.31
ALDH1A1 P00352 2/20 0.30
MAPK1 P28482 1/20 0.30
NISCH Q9Y2I1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3610893 0.82 NFE2L2 (0.36) NFE2L2ACHECYP2A6CYP1A2TDP1
SCHEMBL362051 0.76 ALDH1A1 (0.42) NFE2L2CYP2A6CYP1A2TDP1SMN1; SMN2
SCHEMBL29766167 0.76 ALDH1A1 (0.42) NFE2L2CYP2A6CYP1A2TDP1SMN1; SMN2
SCHEMBL1021714 0.76 TDP1 (0.42) ACHECYP2A6CYP1A2TDP1TP53
SCHEMBL9510477 0.72 CYP1A2 (0.42) CYP2A6CYP1A2ALDH1A1
SCHEMBL636709 0.71 TDP1 (0.42) ACHECYP2A6CYP1A2TDP1TP53
SCHEMBL30645502 0.71 TDP1 (0.42) ACHECYP2A6CYP1A2TDP1TP53
SCHEMBL26118583 0.70 ACHE (0.56) ACHECYP1A2TDP1CYP3A4SMN1; SMN2
SCHEMBL130515 0.69
SCHEMBL29441288 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6683218-B1 REACTING AN ARYL FLUORIDE WITH HALOGENATED HYDROCARBON AND MAGNESIUM; METALLIZATION, BORATING; DISTILLING OUT DIETHYL ETHER OR TETRAHYDROFURAN SOLVENT NIPPON SHOKUBAI CO., LTD. (JP) 2004-01-27 US disclosed
EP-0825195-B1 PRODUCING PROCESS OF FLUOROARYL MAGNESIUM DERIVATIVE AND PRODUCING PROCESS OF (FLUOROARYL)BORANE COMPOUND NIPPON CATALYTIC CHEM IND (JP) 2003-11-12 EP disclosed
US-6057480-A Process for preparing fluoroaryl magnesium derivative and process for preparing (fluoroaryl) borane compound NIPPON SHOKUBAI CO., LTD. (JP) 2000-05-02 US disclosed
EP-0838466-A2 Producing process of (fluoroaryl) borane compound and producing process of tetrakis (fluoroaryl) borate derivative NIPPON SHOKUBAI CO., LTD. (JP) 1998-04-29 EP disclosed
EP-0825195-A1 PROCESS FOR THE PREPARATION OF FLUORINATED ARYLMAGNESIUM DERIVATIVES AND PROCESS FOR THE PREPARATION OF (FLUORINATED ARYL)BORON COMPOUNDS NIPPON SHOKUBAI CO., LTD. (JP) 1998-02-25 EP disclosed