Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741436 | 0.85 | DGAT1 (0.41) | POLBPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL484168 | 0.80 | AR (0.47) | POLBALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL12324101 | 0.73 | POLB (0.45) | POLBPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL3726615 | 0.72 | NPC1 (0.68) | POLBALDH1A1MEN1CASP1CASP7 | |
| SCHEMBL29485612 | 0.72 | NPC1 (0.68) | POLBALDH1A1MEN1CASP1CASP7 | |
| SCHEMBL6602159 | 0.72 | NCF1 (0.61) | POLBCYP1A2 | |
| SCHEMBL2162632 | 0.69 | KDM4E (0.56) | POLBALDH1A1MEN1CASP1CASP7 | |
| SCHEMBL23467163 | 0.69 | CYP11B1 (0.66) | POLBPIK3CAALDH1A1MEN1CASP1 | |
| SCHEMBL440638 | 0.68 | POLB (0.58) | POLBALDH1A1MEN1KMT2AKCNH2 | |
| SCHEMBL31490354 | 0.68 | POLB (0.58) | POLBALDH1A1MEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689772-B1 | ANTINEOPLASTIC AGENTS; OSTEOPOROSIS; POLYCYSTIC KIDNEY DISEASE; ANTIVIRAL AGENTS | WYETH | 2004-02-10 | — | — | US | disclosed |
| US-6521618-B2 | Antineoplastic agents, agents for treatment of osteoporosis and polycystic kidney disease | WYETH | 2003-02-18 | — | — | US | disclosed |