SCHEMBL6741832

SCHEMBL6741832

CCOC(=O)C(C(=O)OCC)C(C)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
LMNA P02545 2/20 0.37
HSD17B10 Q99714 1/20 0.37
KMT2A Q03164 2/20 0.37
NPSR1 Q6W5P4 2/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
RAB9A P51151 1/20 0.37
ALOX15 P16050 1/20 0.36
MGAM O43451 1/20 0.36
GAA P10253 1/20 0.36
SI P14410 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36
SOAT1 P35610 1/20 0.36
POLB P06746 2/20 0.35
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
MMP8 P22894 1/20 0.34
PKM P14618 2/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1784836 0.83 ALDH1A1 (0.39) ALDH1A1LMNAHSD17B10HPGDALOX15
SCHEMBL16781658 0.83 ALDH1A1 (0.39) ALDH1A1LMNAHSD17B10HPGDALOX15
SCHEMBL18376969 0.81 HTT (0.43) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL10863109 0.81 HTT (0.43) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL16772842 0.79 ALDH1A1 (0.36) ALDH1A1LMNAHSD17B10HPGDALOX15
SCHEMBL7346204 0.79 ALDH1A1 (0.36) ALDH1A1LMNAHSD17B10HPGDALOX15
SCHEMBL15534315 0.79 ALOX15 (0.38) ALDH1A1LMNAHSD17B10HPGDALOX15
SCHEMBL6822484 0.79 ALDH1A1 (0.36) ALDH1A1LMNAHSD17B10HPGDALOX15
SCHEMBL1459659 0.79 ALDH1A1 (0.36) ALDH1A1LMNAHSD17B10HPGDALOX15
SCHEMBL3906700 0.79 ALOX15 (0.38) ALDH1A1LMNAHSD17B10HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042372-B1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE SPA (IT) 2004-07-14 EP claimed
CN-1146585-C catalyst component and catalyst for olefin polymerization ض� 2004-04-21 CN claimed
US-20030207754-A1 Process for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US claimed
US-20030207755-A1 Heteroatom containing malonates used in catalysts for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US claimed
US-20030199388-A1 Catalysts for the polymerization of olefins EQUISTAR CHEMICALS, LP 2003-10-23 US claimed
US-6605562-B1 Comprising TiCl4, MgCl2 and an electron donor compound selected from heteroatom containing esters of malonic acids; heteroatoms are preferably selected from F, Cl, Br, and Si BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2003-08-12 US claimed
CN-1292800-A catalyst component and catalyst for olefin polymerization MONTELL TECHNOLOGY COMPANY BV (NL) 2001-04-25 CN claimed
EP-1042372-A1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS Montell Technology Company bv (NL) 2000-10-11 EP claimed
WO-2000026259-A1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS MONTELL TECHNOLOGY COMPANY BV (NL) 2000-05-11 WO claimed
EP-1042372-B1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE SPA (IT) 2004-07-14 EP disclosed
CN-1146585-C catalyst component and catalyst for olefin polymerization ض� 2004-04-21 CN disclosed
US-6699814-B2 CATALYST COMPRISING PRODUCT OF REACTION BETWEEN SOLID CATALYST COMPONENT COMPRISING MAGNESIUM, TITANIUM, HALOGEN AND HETEROATOM CONTAINING MALONATE, ALKYLALUMINUM COMPOUND AND, OPTIONALLY, ONE OR MORE ELECTRON-DONOR COMPOUNDS BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2004-03-02 US disclosed
US-6689850-B2 Process for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2004-02-10 US disclosed
US-20030207754-A1 Process for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US disclosed
US-20030207755-A1 Heteroatom containing malonates used in catalysts for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US disclosed
US-20030199388-A1 Catalysts for the polymerization of olefins EQUISTAR CHEMICALS, LP 2003-10-23 US disclosed
US-6605562-B1 Comprising TiCl4, MgCl2 and an electron donor compound selected from heteroatom containing esters of malonic acids; heteroatoms are preferably selected from F, Cl, Br, and Si BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2003-08-12 US disclosed
CN-1292800-A catalyst component and catalyst for olefin polymerization MONTELL TECHNOLOGY COMPANY BV (NL) 2001-04-25 CN disclosed