SCHEMBL6741847

SCHEMBL6741847

CCOC(=O)C(Cc1ccccc1)(C(=O)OCC)C(C)C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
MMP8 P22894 2/20 0.51
RECQL P46063 1/20 0.51
POLB P06746 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
LMNA P02545 3/20 0.43
TAAR1 Q96RJ0 2/20 0.43
THRB P10828 1/20 0.43
PIN1 Q13526 1/20 0.43
MAPT P10636 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TSHR P16473 2/20 0.40
PPID Q08752 1/20 0.40
HSD17B10 Q99714 1/20 0.40
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27470129 0.86 TAAR1 (0.47) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL6740786 0.85 ALDH1A1 (0.56) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL28260493 0.84 ALDH1A1 (0.55) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL6882983 0.82 SMN1; SMN2 (0.46) ALDH1A1TAAR1SMN1; SMN2TSHRKMT2A
SCHEMBL28261808 0.80 ALDH1A1 (0.55) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL2010765 0.79 ALDH1A1 (0.59) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL5806489 0.75 ALDH1A1 (0.62) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL4419400 0.75 ALDH1A1 (0.62) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL12555524 0.75 POLB (0.65) ALDH1A1MMP8RECQLPOLBNPSR1
SCHEMBL15553682 0.75 ALDH1A1 (0.55) ALDH1A1MMP8RECQLPOLBNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042372-B1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE SPA (IT) 2004-07-14 EP claimed
US-20030207754-A1 Process for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US claimed
US-20030207755-A1 Heteroatom containing malonates used in catalysts for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US claimed
US-20030199388-A1 Catalysts for the polymerization of olefins EQUISTAR CHEMICALS, LP 2003-10-23 US claimed
US-6605562-B1 Comprising TiCl4, MgCl2 and an electron donor compound selected from heteroatom containing esters of malonic acids; heteroatoms are preferably selected from F, Cl, Br, and Si BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2003-08-12 US claimed
US-10954324-B2 Catalyst component for high activity and high stereoselectivity in olefin polymerization FORMOSA PLASTICS CORPORATION, U.S.A. (US) 2021-03-23 US disclosed
US-20180066084-A1 Catalyst Component for High Activity and high Stereoselectivity in Olefin Polymerization FORMOSA PLASTICS CORPORATION, U.S.A. 2018-03-08 US disclosed
US-9815918-B2 Catalyst component for high activity and high stereoselectivity in olefin polymerization FORMOSA PLASTICS CORPORATION, U.S.A. (US) 2017-11-14 US disclosed
US-20130244863-A1 Catalyst Component For High Activity And High Stereoselectivity In Olefin Polymerization FORMOSA PLASTICS CORPORATION, USA (US) 2013-09-19 US disclosed
EP-1042372-B1 COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE SPA (IT) 2004-07-14 EP disclosed
US-6699814-B2 CATALYST COMPRISING PRODUCT OF REACTION BETWEEN SOLID CATALYST COMPONENT COMPRISING MAGNESIUM, TITANIUM, HALOGEN AND HETEROATOM CONTAINING MALONATE, ALKYLALUMINUM COMPOUND AND, OPTIONALLY, ONE OR MORE ELECTRON-DONOR COMPOUNDS BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2004-03-02 US disclosed
US-6689850-B2 Process for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2004-02-10 US disclosed
US-20030207754-A1 Process for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US disclosed
US-20030207755-A1 Heteroatom containing malonates used in catalysts for the polymerization of olefins MORINI GIAMPIERO (IT) 2003-11-06 US disclosed
US-20030199388-A1 Catalysts for the polymerization of olefins EQUISTAR CHEMICALS, LP 2003-10-23 US disclosed
US-6605562-B1 Comprising TiCl4, MgCl2 and an electron donor compound selected from heteroatom containing esters of malonic acids; heteroatoms are preferably selected from F, Cl, Br, and Si BASELL POLIOLEFINE ITALIA S.P.A. (IT) 2003-08-12 US disclosed