Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258578 | 0.89 | CDK5 (0.71) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL3019684 | 0.87 | CDK5 (0.56) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL3708235 | 0.85 | NPC1 (0.63) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL28281356 | 0.82 | CYP19A1 (0.60) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL12124985 | 0.82 | NPC1 (0.75) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL26670120 | 0.81 | KDM4E (0.54) | NPC1RAB9AKDM4EMEN1MAPT | |
| SCHEMBL6534809 | 0.79 | NPC1 (0.71) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL30751167 | 0.79 | NPC1 (0.71) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| 2-Phenyl-1H-Indole SCHEMBL341378 | 0.78 | NPC1 (1.00) | CYP19A1NPC1RAB9AKDM4EMEN1 | |
| 2-Phenyl-1H-Indole SCHEMBL29363616 | 0.78 | NPC1 (1.00) | CYP19A1NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101575331-B | Preparation method of 5'-((5-MethoxyMethoxy-2- phenylindole-1-yl)methylene)-2'-oxo-3'- methylenetetrahydrofuran | SHANGHAI INST MATERIA MEDICA | 2011-07-20 | — | — | CN | disclosed |
| CN-101575331-A | Preparation method of 5'-((5-methoxyl-2-phenyl indole-1-yl) methylene)-2'-oxo-3'-tetrahydrofurfuryl | SHANGHAI INST MATERIA MEDICA (CN) | 2009-11-11 | — | — | CN | disclosed |
| US-20040086983-A1 | Method for producing a heterocyclic compound and an aromatic carboxylic acid having one or more hydroxyl groups, and modified aromatic ring dioxygenase | MARINE BIOTHECHNOLOGY INSTITUTE., LTD. (JP) | 2004-05-06 | — | — | US | disclosed |
| US-4113736-A | NONTOXIC POLYMER STABILIZERS | S. A. LABAZ (BE) | 1978-09-12 | — | — | US | disclosed |