Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | CASP3 | P42574 | 2/20 | 0.63 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741892 | 0.85 | CYP19A1 (0.64) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL21122121 | 0.85 | CDK5 (0.84) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL29437815 | 0.85 | CDK5 (0.84) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL12124985 | 0.82 | NPC1 (0.75) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL5130538 | 0.81 | NPC1 (0.68) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL6534809 | 0.79 | NPC1 (0.71) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL30751167 | 0.79 | NPC1 (0.71) | NPC1RAB9ACASP3SENP8SENP7 | |
| 2-Phenyl-1H-Indole SCHEMBL29363616 | 0.78 | NPC1 (1.00) | NPC1RAB9ACASP3SENP8SENP7 | |
| 2-Phenyl-1H-Indole SCHEMBL341378 | 0.78 | NPC1 (1.00) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL3711446 | 0.78 | NPC1 (0.63) | NPC1RAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104151292-A | Indole derivative or pharmaceutically acceptable salt thereof | KISSEI PHARMACEUTICAL | 2014-11-19 | — | — | CN | disclosed |
| EP-2474530-B1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | KISSEI PHARMACEUTICAL (JP) | 2014-09-03 | — | — | EP | disclosed |
| EP-2474530-A1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-07-11 | — | — | EP | disclosed |
| CN-102498097-A | Indole derivatives or pharmaceutically acceptable salts thereof | KISSEI PHARMACEUTICAL | 2012-06-13 | — | — | CN | disclosed |
| US-20120122931-A1 | INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-4113736-A | NONTOXIC POLYMER STABILIZERS | S. A. LABAZ (BE) | 1978-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122931-A1 | INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | PTGER1, CYSLTR1, LTB4R | NPC1 1150/4885RAB9A 1646/4885CASP3 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.