Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.47 |
| ▸ | NQO2 | P16083 | 2/20 | 0.45 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14003503 | 0.83 | HSD17B10 (0.56) | ALDH1A1MAPK1POLBKITFYN | |
| SCHEMBL16712949 | 0.80 | POLB (0.50) | MAPK1POLBKITFYNBRAF | |
| SCHEMBL22130625 | 0.80 | KMT2A (0.55) | ALDH1A1MAPK1SMN1; SMN2POLBKIT | |
| SCHEMBL15329674 | 0.80 | NQO2 (0.55) | ALDH1A1SMN1; SMN2POLBNQO2MEN1 | |
| SCHEMBL6792137 | 0.78 | CYP17A1 (0.60) | ALDH1A1SMN1; SMN2NQO2MEN1MAPT | |
| SCHEMBL6388380 | 0.78 | NOX4 (0.60) | ALDH1A1MAPK1HPGDSMN1; SMN2MAPT | |
| SCHEMBL6390614 | 0.78 | NOX4 (0.60) | KIT | |
| SCHEMBL6388381 | 0.78 | NOX4 (0.60) | ALDH1A1MAPK1HPGDSMN1; SMN2MAPT | |
| SCHEMBL6390621 | 0.78 | NOX4 (0.60) | KIT | |
| SCHEMBL16697374 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2AOX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |