Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.45 |
| ▸ | ABAT | P80404 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1206443 | 0.88 | ALDH1A1 (0.53) | ALDH1A1TSHRAOX1TTRFDPS | |
| SCHEMBL16711689 | 0.86 | ALDH1A1 (0.58) | ALDH1A1TSHRAOX1TTRFDPS | |
| SCHEMBL3927724 | 0.85 | TTR (0.54) | ALDH1A1TSHRAOX1TTRFDPS | |
| SCHEMBL3926144 | 0.84 | TTR (0.59) | ALDH1A1TSHRAOX1TTRFDPS | |
| SCHEMBL13578465 | 0.84 | PDE4D (0.52) | ALDH1A1TSHRAOX1TTRFDPS | |
| SCHEMBL29405127 | 0.84 | PDE4D (0.52) | ALDH1A1TSHRAOX1TTRFDPS | |
| SCHEMBL15906120 | 0.82 | ACHE (0.52) | ALDH1A1TSHRHPGDSMN1; SMN2NPC1 | |
| SCHEMBL3920365 | 0.81 | ALDH1A1 (0.70) | ALDH1A1TSHRAOX1TTRFDPS | |
| SCHEMBL16709388 | 0.81 | S1PR4 (0.41) | ALDH1A1HPGDTRIM24TDP1TRIM33 | |
| SCHEMBL16711687 | 0.80 | AKR1C3 (0.49) | ALDH1A1TSHRAOX1TTRFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150133467-A1 | SCREENING METHOD, PROTEIN INSTABILITY AND/OR STABILITY INDUCERS, AND PROTEIN ACTIVITY ASSESSMENT | KYOTO UNIVERSITY (JP) | 2015-05-14 | — | — | US | disclosed |
| US-20150133467-A1 | SCREENING METHOD, PROTEIN INSTABILITY AND/OR STABILITY INDUCERS, AND PROTEIN ACTIVITY ASSESSMENT | KYOTO UNIVERSITY (JP) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133467-A1 | SCREENING METHOD, PROTEIN INSTABILITY AND/OR STABILITY INDUCERS, AND PROTEIN ACTIVITY ASSESSMENT | IGF2BP1, IGF2BP2, IGF2BP3 | ALDH1A1 2338/4885TSHR 3338/4885AOX1 2263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.